A new finding from the Disease Biology Laboratory describes the mechanism of thrombocytopenia (low platelet counts) in dengue patients. Study explains – how dengue virus (DENV) infects and activates platelets. The higher degree of platelet activation is associated with more clearance of platelets from circulations in dengue patients. Several pathways are involved by which the DENV-activated platelets are cleared from circulations. The activated-platelets are 1) phagocytized by monocytes and macrophages, 2) aggregated or agglutinated and depleted from circulation, and 3) lysed by antibody-complement factors. Further this study shows that a careful strategy of inactivation of platelets may rescue them from the DENV-mediated rapid clearance.
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