Category: Science News@RCB

Molecular Approaches for Analysis of Drosophila MicroRNAs

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MicroRNAs (miRNAs) belong to a class of small non-coding endogenous RNAs that regulate gene expression at the post-transcriptional level. These small RNAs recognize sequences within 3′ untranslated regions of target mRNAs in complexes referred to as a miRNA-induced silencing complex (miRISC). Drosophila melanogaster has served as an indispensable model system for defining the diverse biological roles of […]

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Genome Sequence of a Potential Plant Growth-Promoting Rhizobacterium, Pseudomonas sp. Strain CK-NBRI-02

Pseudomonas sp. strain CK-NBRI-02 is a potential plant growth-promoting Gram-negative rhizobacterium isolated from the rhizosphere of maize plants growing in fields in Srinagar, Jammu, and Kashmir, India. Here, we report a 5.25-Mb draft assembly of the genome sequence of Pseudomonas sp. strain CK-NBRI-02(or P2; GenBank ID: VSJH00000000) with an average G+C content of 62.47%. Deeper analysis of its genome […]

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Detection of Phytopathogenic Fungal strains

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Phytopathogens infect a large number of economically important plants resulting in massive yield loss globally. The effective and early detection strategy is the first measure to control the disease outbreak. Currently, the diagnosis of phytopathogenic fungus relies on traditional staining and culture techniques, however, they face major limitations such as – need to culture the […]

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Chaperone mechanism of DJ-1

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DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in inhibiting the aggregation of α-synuclein, a key protein associated with Parkinson’s disease. The underlying molecular mechanism behind α-synuclein aggregation inhibition remains unknown. Here we report that the partially oxidized DJ-1 possesses an adhesive surface which sequesters […]

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SpaB, an atypically adhesive basal pilin from the lactobacillar SpaCBA pilus: crystallization and X-ray diffraction analysis

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Microbial attachment to host surfaces is a critical step in colonization. Hence, interfering with the initial attachment is considered as one of the attractive and efficient approaches in improving health and combating infections. Towards providing the essential foundations for this approach, Dr Krishnan’s structural biology group currently focus on hair-like surface organelles called pili or […]

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