Monthly Archives: February 2020

Proteome Analyses Reveal Macrophomina phaseolina’s Survival Tools When Challenged by Burkholderia contaminans NZ

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 A phytopathogenic fungus, Macrophomina phaseolina, which infects a wide range of plants, is an important consideration in agronomy. Its management is made mostly through the use of fungicidal chemicals or by crop rotation. However, no such strategies have been successful in eliminating the fungus from the soil and therefore the risk of its infection remains inevitable. […]

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Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson’s disease

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Parkinson’s disease (PD) is a multifactorial malady and the second most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in the midbrain. A hallmark of PD pathology is the formation of intracellular protein inclusions, termed Lewy bodies (LBs). Recent MS studies have shown that OTU deubiquitinase ubiquitin aldehyde binding 1 (OTUB1), a deubiquitinating enzyme […]

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