Monthly Archives: October 2020

eIF2α interactions with mRNA control accurate start codon selection by the translation preinitiation complex

Post Image

Accurate identification of the translation initiation codon is critical to ensure the synthesis of the correct cellular proteins in the proper amounts. In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation […]

Read more