Monthly Archives: March 2022

Pfprex from Plasmodium falciparum can bypass oxidative-stress induced DNA lesions

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Apicomplexans such as the malaria parasite Plasmodium falciparum possess a unique organelle known as the apicoplast that has its own circular genome. The apicoplast genome is AT rich and is subjected to oxidative stress from the byproducts of the normal biochemical pathways that operate in the apicoplast. It is expected that oxidative stress will lead […]

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The Medicago truncatula genome: a powerful resource for identifying novel resistance factors against legume powdery mildews

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Powdery mildew is a serious fungal disease that significantly reduces the productivity of grain and forage legumes worldwide. Due to the harmful effects of fungicides and the high risk of generating fungicide-resistant fungal strains, the use of genetic means to develop resistant legume cultivars has emerged as the preferred strategy for powdery mildew disease management. […]

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Medicarpin confers powdery mildew resistance in Medicago truncatula and activates the salicylic acid signaling pathway

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Powdery mildew is a widespread fungal disease that causes significant reduction in total biomass and seed quality of agriculturally important legumes, including pea and mung bean. With the long-term goal of developing an eco-friendly and sustainable strategy for powdery mildew disease management, we studied the role of a class of plant secondary metabolites – isoflavonoids […]

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TLE4 regulates muscle stem cell quiescence and differentiation.

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Our skeletal muscle has an extraordinary capability to regenerate following muscle damage due to injury or disease. A muscle resident pool of stem cells known as satellite cells are essential for skeletal muscle regeneration. Under normal conditions (homeostasis), the satellite cells remain largely dormant (quiescent), but get activated upon muscle injury, leading them to divide […]

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