Comparative study of 7S globulin from Corylus avellana and Solanum lycopersicum revealed importance of salicylic acid and Cu-binding loop in modulating their function.

We had recently shown that vicilins could exhibit superoxide dismutase activity. In the present study, we have carried out functional and structural analyses of vicilins from two distinct evolutionary sources – tomato (S. lycopersicum; SL80.1) and hazelnut (C. avellana; HZ.1) – towards understanding the basis of their functional diversity. It was identified that SL80.1 retained the activity and HZ.1 lacked the same. We then determined and compared the crystal structures of SL80.1 and HZ.1. It was revealed that the permutation-combination of numerous mutations at different sites could have resulted in gain or loss of the enzymatic activity among vicilins from evolutionarily different sources.

For full article: https://www.sciencedirect.com/science/article/pii/S0006291X19321928?via%3Dihub

 

 

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