Lactate dehydrogenase and GPDH1 cooperatively regulate redox balance during Drosophila larval growth.

 Drosophila melanogaster larval development is characterized by considerable growth and Lactate dehydrogenase (LDH) is crucial for this process because it helps to maintain redox balance within cells by regenerating NAD+ from NADH.  As part of Dr. Jason Tennessen’s team at Indiana University, Dr. Geetanjali Chawla participated in a study that highlight’s the metabolic flexibility of Drosophila larval development. This study shows that flies compensate for the absence of LDH function by upregulating GPDH1 activity. These findings are relevant to cancer therapy, as LDH inhibition has been proposed to interfere with tumour growth, but may instead be counteracted by cancer cells employing alternative metabolic pathways for growth.

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