Category: Science News@RCB

Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation

Tumor suppressor cylindromatosis protein (CYLD), which specifically cleaves lysine 63-linked ubiquitin chain from its substrate molecules, contributes to myriad of important cellular events including cellular differentiation, oncogenesis, DNA repair and cell cycle control. It is a ubiquitously expressed protein, which negatively regulates NF-kB and JNK signaling pathways and mediates caspase dependent apoptosis through RIP1 deubiqutination. […]

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“Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction”

Kottur J, Nair DT. Pyrophosphate hydrolysis is an intrinsic and critical stepof the DNA synthesis reaction. Nucleic Acids Res. 2018 May 30 DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the genome in all living organisms. dPols catalyze the formation of a phosphodiester bond between the incoming deoxynucleoside triphosphate and […]

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Dimerization through the RING-Finger Domain Attenuates Excision Activity of the piggyBac Transposase.

Transposons are mobile genetic elements and their movement give rise to changes in the genome. These elements were discovered by Barbara McClintock and she was awarded the Nobel Prize for this discovery in 1983. The transposons usually code for enzymes known as transposases which are responsible for the movement of these mobile genetic elements. The […]

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Assessing Nano Carbon

00In their native form nanocarbon materials are insoluble in most common solvents, including water. This has been the biggest limitation in their use. A way has now been found around this problem. This is done by functionalization/ derivatization generating multiple polar carboxylic acid groups on their surface. This renders them water soluble and provides sites […]

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Engulfment of Hb-activated platelets differentiates monocytes into pro-inflammatory macrophages in PNH patients.

The distinct response shown by different phenotypes of macrophages and monocytes under various clinical conditions have put the heterogeneity of these cells into focus of investigation for several diseases. Recently we have described that after engulfing Hb-activated platelets, classical monocytes differentiated into pro-inflammatory phenotypes, which were abundant in the circulation of PNH and SCD patients. […]

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