Category: Science News@RCB

Localized drug delivery

Hydrogel based localized drug delivery has major advantages over the conventional systemic and oral drug delivery in terms of maintaining therapeutic concentration of the drugs at the target site and minimal concentration in rest of the major organs of the body, sparing them of the undesired side effects and toxicity. Doxorubicin (DOX) and Docetaxel (DTX) […]

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Tamoxifen-Phospholipid Conjugate: A Promising Anticancer Therapeutic with Improved Antitumor Activity and Reduced Liver Toxicity.

Gynecological cancers such as breast cancer is rapidly rising in India. Surgical resection of breast tumors is the main form of therapy. To reduce the recurrence of tumors in breast cancer patients, Tamoxifen (anticancer drug) is administered daily as oral tablets up to 1-2 years. Acidic pH of stomach precipitates the Tamoxifen, thereby requiring frequent […]

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Modulation of angiogenesis by bile acids is a promise for future therapeutics

Dr. Avinash Bajaj’s lab is primarily focused in the development and finding of new drug delivery molecules and bio-inspired materials for the betterment of conventional chemotherapeutic strategies. Over the years his group exploited bile acids in developing cancer targeting cationic lipids, bile acid based drug conjugates, and further designed bile acid-phosphocholine- derived phospholipids for drug […]

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Unusual Products from ‘long-lived’ Transients (“singlet nitrenes”)

Aryl azides are described as “green reagents as, on heating or on exposure to light, these lead to only a benign loss of nitrogen. In a series of papers on aryl azides Prof. Eswaran’s group have shown their use in “Click” reaction, Solar cells, photomicrolithography & as chemical crosslinkers for studies on protein-protein interactions. Thermolysis […]

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Self-assembled novel phospholipids that controls the drug delivery

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Dr. Avinash Bajaj’s lab is involved in the development of new drug delivery systems that tackle the problems of conventional therapy. Drug encapsulation efficacy and release kinetic parameters are critical for the efficacy of liposomal formulations. In this present research; they designed three bile acid- phosphocholine- derived phospholipids that control the encapsulation and release of […]

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