Category: Science News@RCB

A synthetic non-hemolytic polymer specific for planktonic as well as localized mycobacteria.

Dr. Bajaj’s group at RCB in collaboration with Dr. Aasheesh Srivastava from IISER Bhopal are making continuous efforts towards exploring novel antibacterial molecules that could evade the problem of antimicrobial resistance by targeting bacterial membrane. For targeting an even challenging mycobacterial membrane, they are developing amphiphiles to act brilliantly against the hydrophobic lipid rich membranes […]

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SUMOylation alteration coupled with downregulation of SUMO-E2 enzyme at mucosal epithelium modulate inflammation in Inflammatory Bowel Disease

Dr. C. V. Srikanth’s group at Laboratory of Gut Infection and Inflammation Biology (LGIIB) of Regional Centre for Biotechnology, Faridabad have embarked studies using a multipronged approach on inflammatory bowel disease (IBD). IBD is an intestinal autoimmune disorder involving recurrent and abnormal immune activation resulting in a major healthcare challenge. In this work Salman Mustfa, […]

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Ojha A et al. explains – how dengue virus activates platelets and cause thrombocytopenia?

A new finding from the Disease Biology Laboratory describes the mechanism of thrombocytopenia (low platelet counts) in dengue patients. Study explains – how dengue virus (DENV) infects and activates platelets. The higher degree of platelet activation is associated with more clearance of platelets from circulations in dengue patients. Several pathways are involved by which the […]

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How do bacteria regulate the flagellar numbers ?

The ability to perceive a stimulus and respond appropriately is the hallmark of any living organism. Bacteria respond to environment stimulus by translocating to a more favorable milieu. Bacterial motility is mediated by the action of flagella that are complex dynamic structures composed of numerous proteins. A research paper published in Structureby Dr. Jain’s group […]

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The mechanism of platelet activation by extracellular hemoglobin in sickle cell disease

A recent study from the Disease Biology Lab led by Dr. Prasenjit Guchhait’s uncovered the mechanism of platelet activation by free-hemoglobin in circulation in patients with sickle cell disease (SCD). The group had already described the mechanism of activation of circulating platelets by free-Hb in PNH  patients. This study further shows that sickle hemoglobin Hb […]

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