Category: Science News@RCB

Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced α-Synuclein Fibrillation and Cytotoxicity

Deposition of pre-synaptic protein α-synuclein in Lewy bodies and Lewy neurites in the substantia nigra region of brain has been linked with the clinical symptoms of the Parkinson’s disease (PD). Proteotoxic stress conditions and mutations that cause abnormal aggregation of α-synuclein have close association with onset of PD and its progression. Therefore, studies pertaining to […]

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SPRY2 is a novel MET interactor that regulates metastatic potential and differentiation in rhabdomyosarcoma

Masum Saini, Aakanksha Verma and Sam J. Mathew Rhabdomyosarcoma (RMS) is a predominantly pediatric soft-tissue cancer where the tumor cells exhibit characteristics of the developing skeletal muscle, and the two most common sub-types are embryonal and alveolar RMS. Elevated activation of the receptor tyrosine kinase (RTK) MET is frequent in RMS and is thought to […]

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Mechanism of formation of a toroid around DNA by the mismatch sensor protein

The DNA mismatch repair (MMR) pathway removes errors that appear during genome replication. MutS is the primary mismatch sensor and forms an asymmetric dimer that encircles DNA to bend it to scan for mismatches. The mechanism utilized to load DNA into the central tunnel was unknown and the origin of the force required to bend […]

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Localized drug delivery

Hydrogel based localized drug delivery has major advantages over the conventional systemic and oral drug delivery in terms of maintaining therapeutic concentration of the drugs at the target site and minimal concentration in rest of the major organs of the body, sparing them of the undesired side effects and toxicity. Doxorubicin (DOX) and Docetaxel (DTX) […]

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Tamoxifen-Phospholipid Conjugate: A Promising Anticancer Therapeutic with Improved Antitumor Activity and Reduced Liver Toxicity.

Gynecological cancers such as breast cancer is rapidly rising in India. Surgical resection of breast tumors is the main form of therapy. To reduce the recurrence of tumors in breast cancer patients, Tamoxifen (anticancer drug) is administered daily as oral tablets up to 1-2 years. Acidic pH of stomach precipitates the Tamoxifen, thereby requiring frequent […]

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