Category: Science News@RCB

Modulation of angiogenesis by bile acids is a promise for future therapeutics

Dr. Avinash Bajaj’s lab is primarily focused in the development and finding of new drug delivery molecules and bio-inspired materials for the betterment of conventional chemotherapeutic strategies. Over the years his group exploited bile acids in developing cancer targeting cationic lipids, bile acid based drug conjugates, and further designed bile acid-phosphocholine- derived phospholipids for drug […]

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Unusual Products from ‘long-lived’ Transients (“singlet nitrenes”)

Aryl azides are described as “green reagents as, on heating or on exposure to light, these lead to only a benign loss of nitrogen. In a series of papers on aryl azides Prof. Eswaran’s group have shown their use in “Click” reaction, Solar cells, photomicrolithography & as chemical crosslinkers for studies on protein-protein interactions. Thermolysis […]

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Self-assembled novel phospholipids that controls the drug delivery

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Dr. Avinash Bajaj’s lab is involved in the development of new drug delivery systems that tackle the problems of conventional therapy. Drug encapsulation efficacy and release kinetic parameters are critical for the efficacy of liposomal formulations. In this present research; they designed three bile acid- phosphocholine- derived phospholipids that control the encapsulation and release of […]

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A synthetic non-hemolytic polymer specific for planktonic as well as localized mycobacteria.

Dr. Bajaj’s group at RCB in collaboration with Dr. Aasheesh Srivastava from IISER Bhopal are making continuous efforts towards exploring novel antibacterial molecules that could evade the problem of antimicrobial resistance by targeting bacterial membrane. For targeting an even challenging mycobacterial membrane, they are developing amphiphiles to act brilliantly against the hydrophobic lipid rich membranes […]

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SUMOylation alteration coupled with downregulation of SUMO-E2 enzyme at mucosal epithelium modulate inflammation in Inflammatory Bowel Disease

Dr. C. V. Srikanth’s group at Laboratory of Gut Infection and Inflammation Biology (LGIIB) of Regional Centre for Biotechnology, Faridabad have embarked studies using a multipronged approach on inflammatory bowel disease (IBD). IBD is an intestinal autoimmune disorder involving recurrent and abnormal immune activation resulting in a major healthcare challenge. In this work Salman Mustfa, […]

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