Monthly Archives: June 2018
Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation
- June 4, 2018
- Science News@RCB
- rcb
- 1 Comment.

Tumor suppressor cylindromatosis protein (CYLD), which specifically cleaves lysine 63-linked ubiquitin chain from its substrate molecules, contributes to myriad of important cellular events including cellular differentiation, oncogenesis, DNA repair and cell cycle control. It is a ubiquitously expressed protein, which negatively regulates NF-kB and JNK signaling pathways and mediates caspase dependent apoptosis through RIP1 deubiqutination. […]
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