Monthly Archives: October 2020
eIF2α interactions with mRNA control accurate start codon selection by the translation preinitiation complex
- October 14, 2020
- Science News@RCB
- IT RCB
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Accurate identification of the translation initiation codon is critical to ensure the synthesis of the correct cellular proteins in the proper amounts. In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation […]
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