Author Archives: rcb
Mouse genetic models to understand human musculoskeletal disease
Myosins are proteins which are present in all cell types, essential for fundamental cellular functions such as cell movement, cell division and transport of cargoes within cells. A specialized set of myosin proteins known as muscle myosins are expressed by the skeletal muscle, which are required for muscle contraction. While most muscle myosin proteins are […]Read more
Proteome Analyses Reveal Macrophomina phaseolina’s Survival Tools When Challenged by Burkholderia contaminans NZ
A phytopathogenic fungus, Macrophomina phaseolina, which infects a wide range of plants, is an important consideration in agronomy. Its management is made mostly through the use of fungicidal chemicals or by crop rotation. However, no such strategies have been successful in eliminating the fungus from the soil and therefore the risk of its infection remains inevitable. […]Read more
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson’s disease
Parkinson’s disease (PD) is a multifactorial malady and the second most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in the midbrain. A hallmark of PD pathology is the formation of intracellular protein inclusions, termed Lewy bodies (LBs). Recent MS studies have shown that OTU deubiquitinase ubiquitin aldehyde binding 1 (OTUB1), a deubiquitinating enzyme […]Read more
Enzymatic and Non‐enzymatic Detoxification of Reactive Carbonyl Compounds Improves the Oxidative Stress Tolerance in Cucumber, Tobacco and Rice Seedlings.
A research article published in Journal of Plant Growth Regulators by Dr Ramu Vemanna from RCB in collaboration with Dr Udayakumar’s group at UASB highlights the importance of scavenging reactive carbonyl compounds (RCC) that are generated under stress using enzymatic and non-enzymatic modes to improve seedling growth. Seedling growth during crop establishment plays an important […]Read more
The adhesive PitA pilus protein from the early dental plaque colonizer Streptococcus oralis: expression, purification, crystallization and X-ray diffraction analysis.
Streptococcus oralis is an early colonizer of dental plaque or oral biofilm that can damage our tooth enamel and gums, and cause dental caries (tooth decay). This opportunistic pathogen is often implicated in the pathogenesis of infective endocarditis. The adhesin present at the tip of pili (or fimbriae), the hair-like surface appendages on the early-colonizer bacteria, […]Read more