Author Archives: rcb

A novel SUMOylation switch of Rab7 governs the intracellular life of gastric pathogen Salmonella

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A collaborative effort involving interdisciplinary domains from Dr. C. V. Srikanth and Dr. Vengadesan Krishnan addresses a fascinating mechanism involved in host-pathogen interactions. Several particularly problematic bacterial pathogens require a sophisticated type III secretion system, and a number of type III secreted effectors, to colonize their hosts and subsequently cause disease. Secreted effectors are key […]

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Japanese Encephalitis Virus-induced let-7a/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation.

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 In this study, we have shown that microRNAs (miRNAs) released from the activated microglia upon Japanese Encephalitis virus (JEV) infection may exacerbate CNS damage. We have provided evidence that let-7a and let-7b (let-7a/b secrete through the vesicles from microglial cells in response to JEV infection and induces caspase activation in the primary cortical neurons that are […]

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Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection Using Drosophila as a Model System.

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    Tree of Taste: Taste buds on a human tongue connect to brain and brain decides whether food is palatable or not. Similarly, small insects like Drosophila (fruit fly) has taste buds too. They have hair like structure called sensillum that contain taste neurons (green- leaf like shape) present on the fly mouth and […]

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Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses

Potential target for developing anti-viral drugg Amrita Ojha et al. described how the elevated level of a platelet cytokine, PF4 enhanced the replication and infection of Dengue and Japanese Encephalitis (JE) in patients and in mice. They have described that the treatment with AMG487, a small molecule antagonist to CXCR3 (the receptor of PF4) abrogated […]

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Expose-Ligate-Seal mechanism of bacterial pilus assembly

Bacteria often assemble and use hair-likeorganelles known as pili or fimbriae on their cell surface to quickly and effectively mediate attachment to the host surfaces.This initial attachment is the critical event in bacterial colonization, which may benefit or harm the host depending on nature of their relationship.Dr. VengadesanKrishnan’s structural microbiology research group has begun structural […]

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