Category: Science News@RCB

Proteome Analyses Reveal Macrophomina phaseolina’s Survival Tools When Challenged by Burkholderia contaminans NZ

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 A phytopathogenic fungus, Macrophomina phaseolina, which infects a wide range of plants, is an important consideration in agronomy. Its management is made mostly through the use of fungicidal chemicals or by crop rotation. However, no such strategies have been successful in eliminating the fungus from the soil and therefore the risk of its infection remains inevitable. […]

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Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson’s disease

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Parkinson’s disease (PD) is a multifactorial malady and the second most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in the midbrain. A hallmark of PD pathology is the formation of intracellular protein inclusions, termed Lewy bodies (LBs). Recent MS studies have shown that OTU deubiquitinase ubiquitin aldehyde binding 1 (OTUB1), a deubiquitinating enzyme […]

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Enzymatic and Non‐enzymatic Detoxification of Reactive Carbonyl Compounds Improves the Oxidative Stress Tolerance in Cucumber, Tobacco and Rice Seedlings.

A research article published in Journal of Plant Growth Regulators by Dr Ramu Vemanna from RCB in collaboration with Dr Udayakumar’s group at UASB highlights the importance of scavenging reactive carbonyl compounds (RCC) that are generated under stress using enzymatic and non-enzymatic modes to improve seedling growth. Seedling growth during crop establishment plays an important […]

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The adhesive PitA pilus protein from the early dental plaque colonizer Streptococcus oralis: expression, purification, crystallization and X-ray diffraction analysis.

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Streptococcus oralis is an early colonizer of dental plaque or oral biofilm that can damage our tooth enamel and gums, and cause dental caries (tooth decay). This opportunistic pathogen is often implicated in the pathogenesis of infective endocarditis. The adhesin present at the tip of pili (or fimbriae), the hair-like surface appendages on the early-colonizer bacteria, […]

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High resolution structural and functional analysis of a hemopexin motif protein from Dolichos

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The high-resolution crystal structure of DC25, a 2S albumin protein from Dolichos, at 1.28 Å resolution is reported. The protein has β-propeller structure with a central channel containing only water molecules while the proteins having similar folds have ions along with water or ions only. The four conserved water molecules were found between the blades […]

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