Category: Science News@RCB

Vitamin B12 May Inhibit RNA-Dependent-RNA Polymerase Activity of nsp12 from the SARS-CoV-2 Virus

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SARS‐CoV‐2 is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive‐sense single‐stranded RNA genome. The genome encodes for the nsp12 protein, which houses the RNA‐dependent‐RNA polymerase (RdRP) activity responsible for the replication of the viral genome. A […]

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Defeating the devil in the waste: Remediation of infectious Covid-19 waste

Pictures of Covid-19 waste floating in the sea and rivers, scattered waste outside the garbage bins and stray animals carrying mask in their mouths are in circulation on social media. Low-income countries with weak health systems, crowded megacities and large populations of impoverished people are facing huge challenge to dispose Covid-19 biomedical waste generated every […]

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Structural basis of probiotic LGG adhesion to the gut

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Use of antibiotics is not only developing resistance but also destroying the gut microbiota that we earned since birth. Hence the search for alternative approaches including the use of probiotics is being explored. The probiotics are well known for their beneficial effects, including inhibition of colonization by harmful microbes. One of the vital criteria in […]

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Orai3: Oncochannel with therapeutic potential

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Ion channels in particular Calcium (Ca2+) channels play a critical role in physiology by regulating plethora of cellular processes ranging from cell proliferation, differentiation, transcriptional regulation and programmed cell death. One of the most ubiquitous and highly regulated cellular Ca2+ influx pathways is Store Operated Calcium Entry (SOCE) mediated by Orai1-3 channels. Orai channels are […]

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The proofreading activity of Pfprex from Plasmodium falciparum can prevent mutagenesis of the apicoplast genome by oxidized nucleotide

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The DNA polymerase module of the Pfprex enzyme (PfpPol) is responsible for duplication of the genome of the apicoplast organelle in the malaria parasite. We show that PfpPol can misincorporate oxidized nucleotides such as 8oxodGTP opposite dA. This event gives rise to transversion mutations that are known to lead to adverse physiological outcomes. The apicoplast […]

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