Category: Science News@RCB

eIF2α interactions with mRNA control accurate start codon selection by the translation preinitiation complex

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Accurate identification of the translation initiation codon is critical to ensure the synthesis of the correct cellular proteins in the proper amounts. In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation […]

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Ribosomal protein QM/RPL10 positively regulates defense and protein translation mechanisms during nonhost disease resistance.

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Ribosomes play an integral part in plant growth, development and defense responses. We report that the Ribosomal protein QM/RPL10 and its interacting proteins RNA recognition motif (RRM), RPL30, RPL23, and RPS30 have extra-ribosomal functions and play a role in nonhost disease resistance. The RPL10-silenced Nicotiana benthamiana plants showed compromised disease resistance against nonhost pathogen Pseudomonas […]

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Vitamin B12 May Inhibit RNA-Dependent-RNA Polymerase Activity of nsp12 from the SARS-CoV-2 Virus

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SARS‐CoV‐2 is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive‐sense single‐stranded RNA genome. The genome encodes for the nsp12 protein, which houses the RNA‐dependent‐RNA polymerase (RdRP) activity responsible for the replication of the viral genome. A […]

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Defeating the devil in the waste: Remediation of infectious Covid-19 waste

Pictures of Covid-19 waste floating in the sea and rivers, scattered waste outside the garbage bins and stray animals carrying mask in their mouths are in circulation on social media. Low-income countries with weak health systems, crowded megacities and large populations of impoverished people are facing huge challenge to dispose Covid-19 biomedical waste generated every […]

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Structural basis of probiotic LGG adhesion to the gut

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Use of antibiotics is not only developing resistance but also destroying the gut microbiota that we earned since birth. Hence the search for alternative approaches including the use of probiotics is being explored. The probiotics are well known for their beneficial effects, including inhibition of colonization by harmful microbes. One of the vital criteria in […]

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