Category: Science News@RCB

Expose-Ligate-Seal mechanism of bacterial pilus assembly

Bacteria often assemble and use hair-likeorganelles known as pili or fimbriae on their cell surface to quickly and effectively mediate attachment to the host surfaces.This initial attachment is the critical event in bacterial colonization, which may benefit or harm the host depending on nature of their relationship.Dr. VengadesanKrishnan’s structural microbiology research group has begun structural […]

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Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation

Tumor suppressor cylindromatosis protein (CYLD), which specifically cleaves lysine 63-linked ubiquitin chain from its substrate molecules, contributes to myriad of important cellular events including cellular differentiation, oncogenesis, DNA repair and cell cycle control. It is a ubiquitously expressed protein, which negatively regulates NF-kB and JNK signaling pathways and mediates caspase dependent apoptosis through RIP1 deubiqutination. […]

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“Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction”

Kottur J, Nair DT. Pyrophosphate hydrolysis is an intrinsic and critical stepof the DNA synthesis reaction. Nucleic Acids Res. 2018 May 30 DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the genome in all living organisms. dPols catalyze the formation of a phosphodiester bond between the incoming deoxynucleoside triphosphate and […]

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Dimerization through the RING-Finger Domain Attenuates Excision Activity of the piggyBac Transposase.

Transposons are mobile genetic elements and their movement give rise to changes in the genome. These elements were discovered by Barbara McClintock and she was awarded the Nobel Prize for this discovery in 1983. The transposons usually code for enzymes known as transposases which are responsible for the movement of these mobile genetic elements. The […]

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Assessing Nano Carbon

00In their native form nanocarbon materials are insoluble in most common solvents, including water. This has been the biggest limitation in their use. A way has now been found around this problem. This is done by functionalization/ derivatization generating multiple polar carboxylic acid groups on their surface. This renders them water soluble and provides sites […]

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