Category: Science News@RCB

Genetic Regulation of Adult Stem Cell Dynamics

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Adult stem cells (ASCs) with self-renewal and differentiation abilities are present in various organs in the body. Where these ASCs are actively involved in tissue maintenance during homeostasis, injury, as well as infection. The ASCs function requires precise regulation of proliferation, differentiation, survival, and migration. Any irregularities in these processes can inhibit tissue recovery or […]

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A plant sugar transporter contributes to powdery mildew resistance in legumes

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Obligate biotrophic fungal pathogens establish long-term feeding relationships with their plant host, during which they siphon sugars from host cells through haustoria. The Arabidopsis hexose transporter, STP13 (sugar transport protein 13), was previously shown to confer resistance against hemi-biotrophic and necrotrophic pathogens by limiting sugar flux towards these pathogens. By contrast, expression of Lr67res, a […]

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The PHP domain of PolX from Staphylococcus aureus aids high fidelity DNA synthesis through the removal of misincorporated deoxyribo-, ribo- and oxidized nucleotides

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The X family is one of the eight families of DNA polymerases (dPols) and members of this family are known to participate in the later stages of Base Excision Repair. Many prokaryotic members of this family possess a Polymerase and Histidinol Phosphatase (PHP) domain at their C-termini. The PHP domain has been shown to possess […]

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JEV capsid protein interacts with non-lipidated LC3

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¬†Microtubule-associated protein 1 light chain 3 (MAP1LC3) is a protein with a well-defined function in autophagy, but still incompletely understood roles in several other autophagy-independent processess. Studies have shown MAP1LC3 is a host dependency factor for the replication of several viruses. Japanese encephalitis virus (JEV), a neurotropic flavivirus, replicates on ER derived membranes that are […]

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Proteins involved in actin filament organization

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Multiple membrane trafficking networks operate in the eukaryotic cell and are hijacked by viruses to establish infection. Recent studied have highlighted that viruses can exploit distinct pathways depending on the cell type. Japanese encephalitis virus (JEV), a neurotropic flavivirus, can infect neuronal cells through a clathrin-independent endocytic mechanism. To further characterize the membrane trafficking requirements […]

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