• Welcome

    The RCB blog has been created to share views, thoughts and opinions on education, research, training and events happening at and pertinent to RCB. All RCB members are invited to contribute to the blog by writing articles, sharing recent activities and posting comments. You can send your entries to blog@rcb.res.in

    Arrow
    Arrow
    RCB's first PhD student successfully defended Viva Voce - February 2017
    Slider


Effector mining from the Erysiphe pisi haustorial transcriptome identifies novel candidates involved in pea powdery mildew pathogenesis

Powdery mildews are significant fungal pathogens that cause crop yield losses of ~25-60%. They are true obligate biotrophs, which means that they depend entirely on living host plants for their survival. To establish biotrophic relationships with their host, these fungi secrete an arsenal of effector molecules, primarily through specialized infection structures termed haustoria. A research […]

Share
Read more

Scientists use the Chimeric Hydrogel for Targeting the Tumor Progression

Group led by Dr. Avinash Bajaj from Regional Centre for Biotechnology designed a low molecular weight hydrogel that can maintain sustained and sequential release of combination of drugs and inhibit the tumor progression in murine models. Using the bioconjugation strategies and biocompatible bile acid and peptide scaffolds, Dr. Bajaj’s group engineered a biocompatible and biodegradable […]

Share
Read more

Researchers Engineer Cholic Acid-derived Amphiphiles as Potential Antimicrobials against Gram-negative Bacterial and Polymicrobial Infections

Group led by Dr. Avinash Bajaj synthesized twenty cholic acid-peptide conjugates and screened them for different gram-negative bacterial species. They showed that glycine-valine derived cholic acid amphiphile is effective and less haemolytic as compared to other amphiphiles. Various biophysical and biochemical assays validated the membrane-disrupting properties of the amphiphile. MD simulations deciphered that rigidity provided […]

Share
Read more

Understanding Taste Using Drosophila melanogaster

Post Image

Taste is a short-range contact chemosensation required by all animals to detect nutrient rich foods and avoid consuming toxic chemicals. In insects, it is also required to select mates and appropriate oviposition sites. Organization of the fruit fly Drosophila melanogaster taste system and availability of experimental tool box, makes Drosophila gustatory system an ideal model […]

Share
Read more

Quantitative Proteome Analysis of Atg5-Deficient Mouse Embryonic Fibroblasts Reveals the Range of the Autophagy-Modulated Basal Cellular Proteome

Post Image

Autophagy performs housekeeping functions for cells and maintains a functional mode by degrading damaged proteins and organelles and providing energy under starvation conditions. The process is tightly regulated by the evolutionarily conserved Atg genes, of which Atg5 is one such crucial mediator. Here, we have done a comprehensive quantitative proteome analysis of mouse embryonic fibroblasts that lack a functional […]

Share
Read more