Ion channels in particular Calcium (Ca2+) channels play a critical role in physiology by regulating plethora of cellular processes ranging from cell proliferation, differentiation, transcriptional regulation and programmed cell death. One of the most ubiquitous and highly regulated cellular Ca2+ influx pathways is Store Operated Calcium Entry (SOCE) mediated by Orai1-3 channels. Orai channels are […]

The DNA polymerase module of the Pfprex enzyme (PfpPol) is responsible for duplication of the genome of the apicoplast organelle in the malaria parasite. We show that PfpPol can misincorporate oxidized nucleotides such as 8oxodGTP opposite dA. This event gives rise to transversion mutations that are known to lead to adverse physiological outcomes. The apicoplast […]

Present prospective study is designed to find changes in salivary protein expressions from early to middle phase of term pregnancy. To date, a comprehensive characterization of the longitudinal salivary proteome in pregnancy has not been performed, and here first time we establish an expressional trajectory for modulated proteins in pregnancy. The label free proteomics (SWATH-MS) […]

Most cells divide through a highly dynamic but tightly regulated process known as mitosis to help the body grow and develop properly. Mistake(s) during mitosis lead to aberrant growth and development, and often to deadly diseases like cancer. One key event early during mitosis is the proper positioning and orientation of the mitotic spindle within […]

Plants constantly exposed to stress and oxidative stress is ubiquitous. The downstream effect of oxidative stress in terms of generation of Reactive carbonyl compounds (RCC), glycation products were not explored well in plant biology. This review provides an insight that sequence of events happening in the plants and their influence on plant physiology and subsequent […]