Prof. Prasenjit Guchhait’s lab in Regional Centre for Biotechnology, Faridabad, India, has developed a promising antiviral drug for dengue treatment in collaboration with Dr. Shailendra Asthana’s lab in Translational Health Science and Technology Institute, Faridabad. The study was published recently by Gaur KK and Asuru TR et al in the reputed journal EMBO Molecular Medicine. […]
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Figure: (A) Domain organization of ApPol1 (B) Crystal structure of ApPol1 and (C) Computational model of DNA-bound structure of ApPol1. Replication of the genome is carried out high fidelity DNA polymerases in all organisms. The DNA polymerases are classified into seven families among which the A, B, C and D families are composed of high […]
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Rhabdomyosarcoma (RMS) is a soft tissue cancer that occurs predominantly in children and adolescents. RMS tumor cells resemble skeletal muscle cells. However, unlike normal skeletal muscle cells which undergo terminal differentiation, RMS tumor cells do not differentiate. The ability to remain undifferentiated could underlie the tumor-specific properties such as proliferation and metastasis in RMS. In […]
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Cell wall-derived oligosaccharides are often generated during pathogen attacks and plant development, and plants sense them as a danger signal and trigger the immune response. However, how these oligosaccharide signals can reinforce or remodel the cell wall by maintaining its integrity which is not explored in detail. Therefore, this study investigated the role of xylan-derived […]
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Bacteria are versatile organisms that instantly respond to changing environmental signals. Motility in bacteria is mediated by multi-protein complex thread like structure called flagella that allows bacteria to move towards favourable conditions. However, bacteria can also form sessile sedentary surface attached communities embedded in think polysaccharide matrix called biofilms. A research paper published in the […]
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