Horizontal acquisition of HopA1 effectors in Pseudomonas species has endowed expansion in their host range and increased infectivity potentials. HopA1s from P. syringae pv. syringae strain 61 (HopA1pss) but not from the tomato pathovar (HopA1pst) is recognized by Arabidopsis thaliana RESISTANCE TO PSEUDOMONAS SYRINGAE 6 (RPS6) to elicit effector-triggered immunity (ETI). To decipher detection and/or […]

A study was conducted to catalog the miRNAs circulating in the plasma of the patients during dengue infection and identify the miRNAs associated with disease progression. To achieve it, we have used a high-throughput small RNA sequencing approach on plasma samples from dengue patients with varying disease severity and compared the data between the different […]

Adult Mesenchymal stem cells(MSCs) -derived exosomes carry several biologically active molecules. Depending on their origin, the content of their cargo and their functions may vary. This study aimed to get more in-depth insights into the differences and similarities between exosomes isolated from different origins i.e., bone marrow (BM), adipose tissue (AD), and Wharton Jelly (WJ), […]

Microglial cells, the resident macrophages in the brain, play a vital role in Japanese encephalitis virus (JEV) pathogenesis. The deregulated activity of microglia can be lethal for the brain. Interferon regulatory factor 8 (IRF8) is a myeloid lineage transcription factor involved in microglial activation. However, the impact of IRF8 modulation on JEV replication remains elusive. […]

We provide an experimental encephalitis murine model accomplished in 3-4 weeks old C57BL/6 mice. A mouse-adapted isolate of Japanese encephalitis virus (JEV), designated as JEV-S3, was generated by serially passaging the P20778 strain of the virus in 3-4 weeks old C57BL/6 mice. The study indicated that when mice were challenged with JEV-S3 through the intraperitoneal […]