Laboratory of Calciomics and Systemic Pathophysiology (LCSP), Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India 2CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi, India 3Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India *Correspondence: rajender.motiani@rcb.res.in Our recently published study shows that a calcium channel “Orai3” regulates pancreatic cancer metastasis. Pancreatic cancer is one […]

Tuberculosis (TB) is one of the leading causes of death, according to the World Health Organization report a total of 1.5 million people died from TB in 2020 and its the second leading infectious killer after COVID-19 (above HIV/AIDS). TB is caused from a Mycobacterium tuberculosis (M. tuberculosis) bacterium. The increase in M. tuberculosis drug […]

Alpha-ketoglutarate (AKG) is a key molecule that stimulates protein synthesis. It has been found to extend the lifespan of a soil-living roundworm.Biologists at the Regional Centre for Biotechnology in Faridabad, India, have discovered that dietary AKG could alleviate COVID-19-induced lung damage in hamsters1. AKG protects the lungs by reducing clot formation in blood vessels and […]

Dietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their processing factors have been linked to organismal longevity. However, the mechanisms by which they modulate lifespan and the tissue-specific role of miRNA-mediated networks in DR-dependent enhancement of lifespan remains largely unexplored. This study shows […]

Adhesion to the host surface is the prerequisite for bacterial colonization, biofilm formation, and niche adaptation. The bacterial attachment is often facilitated through cell surface appendages called pili. In addition to adhesion, the pili also play a role in biofilm formation, immunomodulation, pathogenesis, and probiotic behaviours. The pili are usually composed of three protein subunits […]