Use of antibiotics is not only developing resistance but also destroying the gut microbiota that we earned since birth. Hence the search for alternative approaches including the use of probiotics is being explored. The probiotics are well known for their beneficial effects, including inhibition of colonization by harmful microbes. One of the vital criteria in […]

Ion channels in particular Calcium (Ca2+) channels play a critical role in physiology by regulating plethora of cellular processes ranging from cell proliferation, differentiation, transcriptional regulation and programmed cell death. One of the most ubiquitous and highly regulated cellular Ca2+ influx pathways is Store Operated Calcium Entry (SOCE) mediated by Orai1-3 channels. Orai channels are […]

The DNA polymerase module of the Pfprex enzyme (PfpPol) is responsible for duplication of the genome of the apicoplast organelle in the malaria parasite. We show that PfpPol can misincorporate oxidized nucleotides such as 8oxodGTP opposite dA. This event gives rise to transversion mutations that are known to lead to adverse physiological outcomes. The apicoplast […]

Present prospective study is designed to find changes in salivary protein expressions from early to middle phase of term pregnancy. To date, a comprehensive characterization of the longitudinal salivary proteome in pregnancy has not been performed, and here first time we establish an expressional trajectory for modulated proteins in pregnancy. The label free proteomics (SWATH-MS) […]