Sortases are cysteine transpeptidase enzymes that decorate the Gram-positive bacterial cell wall with various surface proteins and pili to facilitate the interactions with the host and environment for the colonization. While the sortases and sortase anchored proteins from Gram-positive pathogens have been the prime focus of the research in the past, sortases from many non-pathogenic bacteria, including […]

Dental plaque or oral biofilm is a major cause of periodontal disease, dental caries, and infections such as infective endocarditis. Attachment of pioneer bacteria (primary or early colonizers) to the tooth surfaces (e.g., the acquired salivary pellicle coated on the tooth surface) is the first and critical step in plaque development. Coaggregation between the primary […]