Dietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their processing factors have been linked to organismal longevity. However, the mechanisms by which they modulate lifespan and the tissue-specific role of miRNA-mediated networks in DR-dependent enhancement of lifespan remains largely unexplored. This study shows […]

Adhesion to the host surface is the prerequisite for bacterial colonization, biofilm formation, and niche adaptation. The bacterial attachment is often facilitated through cell surface appendages called pili. In addition to adhesion, the pili also play a role in biofilm formation, immunomodulation, pathogenesis, and probiotic behaviours. The pili are usually composed of three protein subunits […]

Viruses with positive-sense single stranded RNA (+ssRNA) genomes are responsible for different diseases and represent a global health problem. In addition to developing new vaccines that protect against severe illness on infection, it is imperative to identify new antiviral molecules to treat infected patients. The genome of these RNA viruses generally codes for an enzyme […]

Bacterial attachment to host surfaces is the first and critical step in colonization, biofilm formation, and infection. Bacterial ability to attach to biotic and abiotic surfaces is also the primary concern for many medical and food industries. Bacteria often assemble hair-like decorative proteinaceous appendages called pili or fimbriae on their surface to facilitate initial interaction […]

The functional and structural versatility of Ribonucleic acids (RNAs) makes them ideal candidates for overcoming the limitations imposed by small molecule-based drugs.  Hence, RNA-based biopharmaceuticals such as messenger RNA (mRNA) vaccines, antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), microRNA mimics, anti-miRNA oligonucleotides (AMOs), aptamers, riboswitches, and CRISPR-Cas9 are emerging as vital tools for the treatment […]