A new finding from the Disease Biology Laboratory describes the mechanism of thrombocytopenia (low platelet counts) in dengue patients. Study explains – how dengue virus (DENV) infects and activates platelets. The higher degree of platelet activation is associated with more clearance of platelets from circulations in dengue patients. Several pathways are involved by which the […]

The ability to perceive a stimulus and respond appropriately is the hallmark of any living organism. Bacteria respond to environment stimulus by translocating to a more favorable milieu. Bacterial motility is mediated by the action of flagella that are complex dynamic structures composed of numerous proteins. A research paper published in Structureby Dr. Jain’s group […]

A recent study from the Disease Biology Lab led by Dr. Prasenjit Guchhait’s uncovered the mechanism of platelet activation by free-hemoglobin in circulation in patients with sickle cell disease (SCD). The group had already described the mechanism of activation of circulating platelets by free-Hb in PNH  patients. This study further shows that sickle hemoglobin Hb […]

Dr. Prasenjit Guchhait’s lab explains the mechanism of developing pro-inflammatory pathophysiology of monocytes in hemolytic diseases such as PNH and SCD . In these hemolytic disorders, lysis of red blood cells releases huge amounts of free hemoglobin (Hb) into the plasma, which further activates platelets as shown earlier by the same group. The present study […]

Bacterial attachment to the host surfaces is the first and key step in colonization, which may harm or benefit the host based on the natureof host-microbial relationship. Bacteria often assemble and use hair-like organelles known as pili or fimbriae on their cell surface to quickly and effectively mediate attachment. This initial recognition between the bacteria […]