Autophagy performs housekeeping functions for cells and maintains a functional mode by degrading damaged proteins and organelles and providing energy under starvation conditions. The process is tightly regulated by the evolutionarily conserved Atg genes, of which Atg5 is one such crucial mediator. Here, we have done a comprehensive quantitative proteome analysis of mouse embryonic fibroblasts that lack a functional […]

Methylation of genomic DNA can influence the transcription profile of an organism and may generate phenotypic diversity for rapid adaptation in a dynamic environment. M.HpyAXI is a type III DNA methyltransferase present in Helicobacter pylori and is upregulated at low pH. This enzyme may alter the expression of critical genes to ensure the survival of […]

As part of collaborative research Dr. Geetanjali Chawla participated in a study that examined the metabolic remodeling that occurs in macrophages during bacterial infection.  This work has revealed that orthologs of Hypoxia inducible factor 1a (HIF1a) and Lactate dehydrogenase (LDH) are required for macrophage activation, bactericidal function of the immune cells and resistance to infection, […]

The rapidly An opinion article by Dr. Geetanjali Chawla discusses the current status of research in the biology of aging in India and some initiatives that can help India to participate more effectively in the field of aging research and deal with the challenges of the rapidly increasing older population. Full article:  https://medwinpublishers.com/JERHA/JERHA16000105.pdf

The presence of ribonucleotides in DNA can lead to genomic instability and cellular lethality. To prevent adventitious rNTP incorporation, the majority of the DNA polymerases (dPols) possess a steric filter in the form of a bulky residue that stacks against the ribose sugar and clashes with 2’ -OH of incoming ribonucleotide. MsDpo4 from Mycobacterium smegmatis, […]