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    The RCB blog has been created to share views, thoughts and opinions on education, research, training and events happening at and pertinent to RCB. All RCB members are invited to contribute to the blog by writing articles, sharing recent activities and posting comments. You can send your entries to blog@rcb.res.in

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    RCB's first PhD student successfully defended Viva Voce - February 2017
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Metabolite could alleviate lung damage in COVID-19

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Alpha-ketoglutarate (AKG) is a key molecule that stimulates protein synthesis. It has been found to extend the lifespan of a soil-living roundworm.Biologists at the Regional Centre for Biotechnology in Faridabad, India, have discovered that dietary AKG could alleviate COVID-19-induced lung damage in hamsters1. AKG protects the lungs by reducing clot formation in blood vessels and […]

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Conserved microRNA-networks as regulators of healthy lifespan

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Dietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their processing factors have been linked to organismal longevity. However, the mechanisms by which they modulate lifespan and the tissue-specific role of miRNA-mediated networks in DR-dependent enhancement of lifespan remains largely unexplored. This study shows […]

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Crystallization of pilus proteins from gut-dwelling Ligilactobacillus ruminis

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Adhesion to the host surface is the prerequisite for bacterial colonization, biofilm formation, and niche adaptation. The bacterial attachment is often facilitated through cell surface appendages called pili. In addition to adhesion, the pili also play a role in biofilm formation, immunomodulation, pathogenesis, and probiotic behaviours. The pili are usually composed of three protein subunits […]

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Antiviral therapeutics directed against RNA dependent RNA polymerases from positive-sense viruses

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Viruses with positive-sense single stranded RNA (+ssRNA) genomes are responsible for different diseases and represent a global health problem. In addition to developing new vaccines that protect against severe illness on infection, it is imperative to identify new antiviral molecules to treat infected patients. The genome of these RNA viruses generally codes for an enzyme […]

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Targeting pili-mediated attachment for health benefits

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Bacterial attachment to host surfaces is the first and critical step in colonization, biofilm formation, and infection. Bacterial ability to attach to biotic and abiotic surfaces is also the primary concern for many medical and food industries. Bacteria often assemble hair-like decorative proteinaceous appendages called pili or fimbriae on their surface to facilitate initial interaction […]

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