Bacteria assemblevariety of hair-like surface organelles called pili or fimbriae on their surface for multiple purposes including adhesion, biofilm formation, immunomodulation, motility conjugation, and conducting electricity. Subtle differences in the pilus assembly and structure distinguish the bacterial strains and dictate tissue tropism and host specificity. Targeting pili and pili-mediated interaction appear to be a promising […]Read more
RCB's first PhD student successfully defended Viva Voce - February 2017
Freeman-Sheldon Syndrome (FSS) is a genetic disease where patients exhibit musculoskeletal abnormalities such as joint deformities, bent fingers, club feet, curved spine and facial anomalies. FSS patients have compromised movement, respiratory, speech and feeding problems and delayed growth and development. Mutations in the MYH3 gene, a gene belonging to the myosin family which helps in […]Read more
A collaborative effort involving interdisciplinary domains from Dr. C. V. Srikanth and Dr. Vengadesan Krishnan addresses a fascinating mechanism involved in host-pathogen interactions. Several particularly problematic bacterial pathogens require a sophisticated type III secretion system, and a number of type III secreted effectors, to colonize their hosts and subsequently cause disease. Secreted effectors are key […]Read more
Japanese Encephalitis Virus-induced let-7a/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation.
In this study, we have shown that microRNAs (miRNAs) released from the activated microglia upon Japanese Encephalitis virus (JEV) infection may exacerbate CNS damage. We have provided evidence that let-7a and let-7b (let-7a/b secrete through the vesicles from microglial cells in response to JEV infection and induces caspase activation in the primary cortical neurons that are […]Read more
Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection Using Drosophila as a Model System.
Tree of Taste: Taste buds on a human tongue connect to brain and brain decides whether food is palatable or not. Similarly, small insects like Drosophila (fruit fly) has taste buds too. They have hair like structure called sensillum that contain taste neurons (green- leaf like shape) present on the fly mouth and […]Read more