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    The RCB blog has been created to share views, thoughts and opinions on education, research, training and events happening at and pertinent to RCB. All RCB members are invited to contribute to the blog by writing articles, sharing recent activities and posting comments. You can send your entries to blog@rcb.res.in

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    RCB's first PhD student successfully defended Viva Voce - February 2017
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High resolution structural and functional analysis of a hemopexin motif protein from Dolichos

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The high-resolution crystal structure of DC25, a 2S albumin protein from Dolichos, at 1.28 Å resolution is reported. The protein has β-propeller structure with a central channel containing only water molecules while the proteins having similar folds have ions along with water or ions only. The four conserved water molecules were found between the blades […]

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DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells

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Uncontrolled inflammation in the gut is one of the major cause for development of inflammatory bowel disease (IBD), a chronic form of autoimmune disorder. Ulcerative colitis (UC) and Crohn’s disease (CD) are the two common forms of IBD involving intestinal distress with varied manifestations resulting in severely compromised patient lifestyles. More importantly in the recent […]

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Dual RNA-Seq analysis of Medicago truncatula and the pea powdery mildew Erysiphe pisi uncovers distinct host transcriptional signatures during incompatible and compatible interactions and pathogen effector candidates

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Powdery mildew is a serious fungal disease of legumes. A research article published in Genomics by Dr. Chandran’s group provides novel insights into powdery mildew pathogenesis and host resistance mechanisms.  Dual RNA-Seq was used to simultaneously capture host and pathogen transcriptomes at 1 d post-inoculation of resistant and susceptible Medicago truncatula genotypes with the powdery […]

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Lactate dehydrogenase and GPDH1 cooperatively regulate redox balance during Drosophila larval growth.

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 Drosophila melanogaster larval development is characterized by considerable growth and Lactate dehydrogenase (LDH) is crucial for this process because it helps to maintain redox balance within cells by regenerating NAD+ from NADH.  As part of Dr. Jason Tennessen’s team at Indiana University, Dr. Geetanjali Chawla participated in a study that highlight’s the metabolic flexibility of Drosophila larval […]

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Molecular Approaches for Analysis of Drosophila MicroRNAs

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MicroRNAs (miRNAs) belong to a class of small non-coding endogenous RNAs that regulate gene expression at the post-transcriptional level. These small RNAs recognize sequences within 3′ untranslated regions of target mRNAs in complexes referred to as a miRNA-induced silencing complex (miRISC). Drosophila melanogaster has served as an indispensable model system for defining the diverse biological roles of […]

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