Dr. Prasenjit Guchhait’s lab explains the mechanism of developing pro-inflammatory pathophysiology of monocytes in hemolytic diseases such as PNH and SCD . In these hemolytic disorders, lysis of red blood cells releases huge amounts of free hemoglobin (Hb) into the plasma, which further activates platelets as shown earlier by the same group. The present study […]

Bacterial attachment to the host surfaces is the first and key step in colonization, which may harm or benefit the host based on the natureof host-microbial relationship. Bacteria often assemble and use hair-like organelles known as pili or fimbriae on their cell surface to quickly and effectively mediate attachment. This initial recognition between the bacteria […]

Antimicrobial resistance represents a global health problem of escalating intensity. In order to develop new therapeutic strategies, it is important to understand- in fine molecular detail- how antimicrobial agents such as antibiotics achieve function. In the past few years, it has been suggested that antibiotics function through induction of reactive oxygen species (ROS) that damage […]