Dietary alpha-ketoglutarate inhibits SARS CoV-2 infection and rescues inflamed lungs to restore O2 saturation by inhibiting pAkt

Agarwal S, Kaur S et al. suggested a therapeutic approach against COVID-19. They described that an elevated inflammation, thrombosis and apoptotic tissue damage in the lungs causes hypoxemia leading to a decreased oxygen pressure saturation (SpO2) in circulation of SARS CoV-2 infected animals. Alpha-ketoglutarate (αKG) supplementation rescues the inflamed lungs to restore normal SpO2 by increasing PHD2-mediated inhibition of Akt phosphorylation (pAkt), without affecting anti-viral response of T cells and IgG.


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