Dietary alpha-ketoglutarate inhibits SARS CoV-2 infection and rescues inflamed lungs to restore O2 saturation by inhibiting pAkt

Agarwal S, Kaur S et al. suggested a therapeutic approach against COVID-19. They described that an elevated inflammation, thrombosis and apoptotic tissue damage in the lungs causes hypoxemia leading to a decreased oxygen pressure saturation (SpO₂) in circulation of SARS CoV-2 infected animals. Alpha-ketoglutarate (αKG) supplementation rescues the inflamed lungs to restore normal SpO₂ by increasing PHD2-mediated inhibition of Akt phosphorylation (pAkt), without affecting anti-viral response of T cells and IgG.

https://onlinelibrary.wiley.com/doi/10.1002/ctm2.1041